Our Work

Chow CY, Reiter LT. Etiology of Human Genetic Disease on the Fly. Trends Genet. 17: (2017). LINK

Chow CYBringing genetic background into focus. Nature Reviews Genetics. 17(2): (2016).  LINK

Chow CY, Kelsey K, Wolfner MF, Clark AG. Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum. Mol. Gen. 25(4): (2016). LINK     Listen to Clement discuss implications of this study

Chow CY, Avila F, Wolfner MF, Clark AG.  Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PLoS ONE. 10(3): (2015). LINK

Chow CY, Wang X, Riccardi D, Wolfner MF, Clark AG. The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse. PLoS Genet. 11(2): (2015). LINK     see Cornell Chronicle coverage

Chow CY, Wolfner MF, Clark AG. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes.  PNAS. 110(22): 9013-9018 (2013). LINK

Chow CY, Wolfner MF, Clark AG. A large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics. 193(1):177-8 (2013). LINK

Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM,  Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH. Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet. Jun 7(6) (2011). LINK

Im KM, Kirchhoff T, Wang X, Green T, Chow CY, et al. Haplotype Structure in Ashkenazi Jewish BRCA1 and BRCA2 Mutation Carriers. Hum Genet. 130(5):685-99 (2011). LINK

Chow CY, Wolfner MF, Clark AG. The Genetic Basis for Male x Female Interactions Underlying Variation in Reproductive Phenotypes of Drosophila. Genetics. 186(4):1355-65 (2010). LINK

Sirot LK, LaFlamme BA, Stitnik JL, Rubinstein CD, Avila FW, Chow CY, Wolfner, MF. Molecular social interactions: Drosophila melanogaster seminal fluid proteins as a case study. Adv. Genet. 68: 23-56 (2009). LINK

Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH. Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS. Am J Hum Genet. 84(1):85-8 (2009). LINK

Jin N*, Chow CY*, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH and Weisman LS. VAC14 nucleates a protein complex that is essential for the regulation of PI(3,5)P2 levels in yeast and mouse. EMBO J. (27), 3221-34 (2008).  LINK
*co-first authors

Zhang X, Chow CY, Sahenk Z, Shy M, Meisler M, Li J. Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain 131, 1990-2001 (2008). LINK

McKinney B, Chow CY, Meisler M, Murphy G. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes, brain, and behavior 7 (6), 629-38 (2008). LINK

Zhang Y, Zolov S, Chow CY, Slutsky S, Richardson S, Piper R, Yang B, Nau J, Westrick R, Morrison S, Meisler M, Weisman L. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. PNAS 104 (44), 17518-23 (2007). LINK     see press release

Chow CY, Zhang Y, Dowling J, Jin N, Adamska M, Shiga K, Szigeti K, Shy M, Li J, Zhang X, Lupski J, Weisman L, Meisler M. Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448 (7149), 68-72 (2007). LINK     see press relsease